CLEMSON, SC – NOVEMBER 24: Head coach Dabo Swinney of the Clemson Tigers reacts on the sidelines against the South Carolina Gamecocks during their game at Clemson Memorial Stadium on November 24, 2018 in Clemson, South Carolina. (Photo by Streeter Lecka/Getty Images)The Clemson Tigers are expected to make another run toward the College Football Playoff this upcoming season. With Trevor Lawrence and Travis Etienne still leading the offense, the defending champions will be favored in every game on their schedule.ESPN’s FPI suggests that Clemson will be overwhelming favorites heading into each matchup. Only two of its games are projected to be difficult, and both of them are against SEC opponents.Clemson is given an 88.0 percent chance of defeating Texas A&M in Week 2 of the season. However, the Aggies aren’t the toughest test that the Tigers will face.According to the FPI, South Carolina has the best shot to defeat Clemson. To be more precise, it has a 14.9 percent chance of knocking off the defending champs. It makes sense that ESPN sees South Carolina as the top team to hand Clemson a loss. Not only do the Gamecocks have the talent to compete with one of the best programs in the country, but they’ll also have home-field advantage.The FPI only takes regular season games into account. If the Tigers take care of business and make the postseason, then they’ll most likely have to face their toughest opponent of the year.Clemson fans – does the South Carolina game worry you?
The wife of former LTTE Trincomalee District political head Elilan, has been included in the list of candidates by the TNA for the Northern Provincial Council elections from the Jaffna district. Others contesting from Jaffna under the TNA ticket are PLOTE leader Darmalingam Sidharthan and M.K. Sivajilingham.The TNA filed its nomination papers in the other districts in the north as well today. A Muslim candidate has been included in the TNA list for the Mannar District. (Colombo Gazette) TNA General Secretary Mavai Senathirajah, TNA MP Suresh Premachandran and TNA MP M.A Sumanthiran were among those who accompanied Wigneswaran to hand over the nomination papers. The Tamil National Alliance (TNA) handed over its nomination papers for the Northern Provincial Council elections today.TNA Chief Ministerial candidate for the northern polls C.V. Wigneswaran and a TNA delegation handed over the nomination papers for the Jaffna district at the Jaffna District Secretariat.
AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email Justice Department says Pfizer to pay $491M to resolve investigation into Rapamune sales by By Linda A. Johnson, The Associated Press Posted Jul 30, 2013 5:44 pm MDT The U.S. Justice Department said Tuesday that drugmaker Pfizer Inc. will pay almost $491 million to resolve an investigation into illegal marketing of the organ transplant drug Rapamune by a company Pfizer later acquired.Pfizer, the world’s second-biggest drugmaker, had taken a charge to cover the settlement late last year, when it reached a tentative settlement to resolve lawsuits three whistleblowers had filed back in 2005 and 2007. The Justice Department and numerous other government agencies eventually joined in the probe and the lawsuits.On Tuesday, New York-based Pfizer agreed to pay $257.4 million in civil settlements with federal and state governments and a $157.6 million criminal fine. Pfizer also will forfeit $76 million in assets.The Justice Department said the drugmaker Wyeth, which Pfizer bought in October 2009, trained sales representatives to encourage doctors to prescribe Rapamune for uses other than preventing rejection of transplanted kidneys, even giving them bonuses for doing so.Rapamune was approved in 1999, only for use in kidney transplant patients. Federal laws bar drugmakers from promoting drugs for uses not specifically approved by the Food and Drug Administration.But the practice has previously been so rampant that there’s a term for it — off-label marketing — and multiple law firms specialize in pursuing lawsuits over it. Nearly every big drugmaker, including Pfizer, has been prosecuted for it and eventually agreed to big settlements with the government and whistleblowers, who usually are drug store pharmacists or former pharmaceutical sales reps. The record settlement is $3 billion, paid by British drugmaker GlaxoSmithKline PLC.In the Rapamune case, whistleblower Mark Campbell, a Wyeth sales rep for 20 years until he resigned in 2009, alleged Wyeth promoted Rapamune for patients getting liver, lung, heart and other transplants — potentially dangerous uses.“I believe this settlement represents at least a small step towards insuring that pharmaceuticals are promoted in a manner which does not compromise patient safety,” Campbell said in a statement.Pfizer said In a statement that it “was not a subject or target of this matter, and co-operated fully with the government from the time it learned of this investigation in October 2009. That co-operation was acknowledged today by the Justice Department.”Campbell’s lead attorney, Shelley Slade of Vogel, Slade & Goldstein, said the federal and state governments splitting the settlement from Wyeth are still working out how much of that money will go to the three whistleblowers, who worked together on the case. The other two, Marlene Sandler and Scott Paris, were represented by the Grant & Eisenhofer law firm.Pfizer shares rose 13 cents to close at $29.67.___AP Business Writer Marley Seaman in New York contributed to this report.___Linda A. Johnson can be followed at http://twitter.com/LindaJ_onPharma