Facebook0TwitterEmailPrintFriendly分享President Donald Trump has signed into law a $1.5 trillion tax overhaul package, on Friday, December 22, just in time for Christmas as promised. It is the first major overhaul of the nation’s tax laws since 1986, but far from the largest tax cuts in American history as the president claims. President Trump: “I promised the American people a big, beautiful tax cut for Christmas. With final passage of this legislation, that is exactly what they are getting.” Politically, it marks the Republicans’ first major legislative accomplishment of Trump’s presidency. President Trump touted the size of the tax cut, declaring to reporters in the Oval Office before he signed it today that “the numbers will speak.”
https://twitter.com/OfficialSting/status/1121033350607720448 “I’m thrilled to announce that my brand-new Las Vegas residency ‘Sting: My Songs’ will be opening at the legendary Caesars Colosseum in May of 2020!” the musician saidJennifer VelezGRAMMYs Apr 24, 2019 – 11:48 am GRAMMY-winning singer and musician Sting has announced that he is headed to sin city for his own residency.Sting will launch his Las Vegas stay at the Colosseum at Caesars Palace in May 2020. The show, titled “Sting: My Songs,” will be a 16-night run, but it may add additional nights if ticket sales are high, Rolling Stone reports. Currently, the show has dates set May 2020 through early Sept. Twitter Sting Announces Las Vegas Residency At Caesars Palace News Email “I’m thrilled to announce that my brand new Las Vegas residency ‘Sting: My Songs’ will be opening at the legendary Caesars Colosseum in May of 2020!” Sting tweeted. The Las Vegas residency has gone through a kind of transformation that has made room for major names in music, more recently including Cardi B, Drake and Lady Gaga, among others. Tickets for the shows go on sale May 3 at 10 a.m. PT. For more information, visit Sting’s website. Viva Las Vegas: Why Sin City Residencies No Longer Signify A Long Farewell Facebook Sting Announces Las Vegas Residency sting-announces-las-vegas-residency-caesars-palace
reading • Dark mode color scheme is coming to iPhones with iOS 13 At the end of 2018, there were 1.4 billion Apple devices actively used around the globe, the company said in late January during its quarterly earnings report. More than 900 million of them were iPhones.Meanwhile, Apple has more different operating systems than ever before. There’s iOS for iPhones and iPads, MacOS for its computers, tvOS for Apple TV and watchOS for the Apple Watch. Then there’s Apple Pay, iTunes, Apple Music, the App Store, iCloud, HomeKit and various other apps and services. It’s critical that Apple make a strong impression at WWDC with the next versions of its software. See also Apple’s annual developer convention kicked off Monday at the McEnery Convention Center in San Jose, California (fittingly enough for fans of dark mode, the show’s opening video featured the song “I Guess I Should Go to Sleep” by Jack White). The confab is in its 30th year, and it’s the third year for Apple to hold its developer conference in San Jose. The city — the third biggest in California and 10th largest in the US — is about 50 miles south of San Francisco and only about 10 miles from Apple’s headquarters in Cupertino.WWDC is where Apple details its newest software and services that will arrive on devices later in the year. The company may be best known for its hardware, but the seamless integration of its hardware with its software is what sets Apple apart from rivals. Apple’s ability to control every aspect of its products — something that began when Steve Jobs and Steve Wozniak founded the company in 1976 — has been key in making it the most powerful company in tech. Now playing: Watch this: Apple iOS 13: New Siri voice, camera tools, Dark Mode for iPhone New Mac Pro makes its debut, starts at $5,999 Apple gives the iPad its own OS Returning to Apple’s WWDC after 20 years, now with 5 OSes instead of 1 Get all the latest from WWDC 46 Photos See All Dark mode for iOS 13: iPhone’s dark side never looked so good The long-rumored announcement didn’t come as much of a surprise. Just last week, leaked screenshots showing off Apple’s take on dark mode surfaced on 9to5Mac. It’s also worth noting that Google introduced a similar feature for Android Q users at its I/O developer conference last month. Dark Mode comes to Apple iOS Aug 19 • iOS 13 and iPadOS: How to join the beta, use the best new features on your iPhone and iPad 2:45 As of February 24, 83% of Apple’s mobile devices on the market were running iOS 12, the company’s mobile software from late 2018. Another 12% used iOS 11, and 5 percent of devices ran an older version, according to the company’s developer dashboard. By comparison, only about 10% of Android devices ran Google’s latest software, dubbed Pie, as of May 7At the end of Apple’s WWDC presentation last year, the company gave a sneak peak of Project Marzipan, its effort to make it easy to take apps developed for iOS devices to Macs. Its MacOS update released in September included four of Apple’s own apps that originated on iOS — News, Stocks, Voice Memos and Home.. CNET’s Shara Tibken contributed to this story. Jun 30 • iOS 13 and iPadOS public betas: How to download and install them now Post a comment Share your voice Jun 14 • Apple Music vs. Apple Podcast vs. Apple TV: What’s the difference? WWDC 2019 Apple Event Tags Jul 5 • RIP, iTunes. This is what happens to your Apple music now 0 • Apple WWDC 2019 With iOS 13, native Apple apps and interfaces can ditch the white backgrounds in favor of black. James Martin/CNET WWDC, Apple’s annual developers conference, brought the usual slew of software announcements meant to power Apple’s hardware through the new year. Among them: An alternative dark mode color scheme for devices running iOS 13, the newest version of Apple’s operating system for iPhones. Enable it, and your phone will replace the light-colored interfaces in native Apple apps like Maps, Mail and Messages with a much darker design. 9 Photos Mobile Tech Industry Wellness WWDC 2019: A quick visual recap of Apple’s Worldwide Developers Conference keynote
In This Issue. * Pound Sterling pushes higher on labor data… * BOJ bullish on inflation target… * Aussie $ bounces back on signs of inflation… * Gold falls on taper worries… And, Now, Today’s Pfennig For Your Thoughts! UK Unemployment rate falls more than forecast, pushing the sterling higher… Good day. Thanks to Mike for covering the Pfennig for me yesterday; as usual he set the ‘Pfennig-Pfill-in-writer’ bar pretty high. You will be stuck with me the rest of the week, and then we will split responsibilities again next week. Chuck got out of here just in time, as the snow and bitter cold temps slammed back into the area, and apparently our co-workers in NY are experiencing blizzard like conditions. As Mike mentioned, the week has started out as expected with fairly quiet markets due to the holiday and a lack of data releases here in the US. Without anything to focus on here in the US, currency investors moved their attention across the Atlantic where the pound sterling jumped to one year highs. The sterling has been the fastest rising major currency in the past 6 months, jumping almost 8% vs. the US$. A report which showed the UK’s unemployment rate fell to 7.1% in November provided the fuel for sterling’s latest rise. Analysts had been expecting the rate to fall to just 7.3% from last month’s 7.4% reading; and the big improvement now has the rate very close to the BOE’s 7% threshold for starting to tighten policy. The Bank of England predicted this in minutes from its latest Monetary Policy Committee meeting. In those minutes, the members of the MPC said unemployment would likely reach its 7 percent threshold where it will start to consider rate rises ‘materially earlier than previously expected’. But the BOE also said it saw ‘no immediate need’ to raise rates. The BOE hadn’t expected unemployment to approach their threshold for 3 years, and some are now expecting them to lower this threshold instead of risking a pre-mature rate hike which could kill the UK recovery. But with the US FOMC assuring the markets they will keep rates low well into next year, this latest data out of the UK suggests the BOE may be the first of the major developed economies to start out on a rate increase. This is exactly what has helped boost the pound sterling over the past 6 months, and could certainly continue to keep it well bid. The Governor of the Bank of Japan dismissed the need for more monetary easing yesterday and kept monetary policy as inflation continues to creep back into the Japanese economy. The weaker yen has helped inflate import costs which have helped push the overall inflation rate in Japan back above 1%, nearly half way to their 2% goal. Some still think the BOJ will need to get more aggressive in their support of the Japanese economy in order to offset the expected drag created by a sales tax rise scheduled for April. But the BOJ officials want to wait to see signs of a slowdown prior to pumping more money into their economy and maintained their forecast that core consumer inflation will hit 1.3% this year and 1.9% in the next. “Japan’s economy is continuing to recover moderately with consumers recently front-loading spending ahead of the sales tax hike,” the central bank said, adding it expects consumer inflation to move around 1.0-1.5 percent for the time being. The South African rand continued to hold steady after what has been a 3% slump over the first three weeks of 2014. The slide has placed the rand at levels that most believe are oversold; surpassing even the most bearish of the ‘expert’ forecasts. Some brave speculators are now taking positions at these discounted levels, but there is still downside risk with further mining strikes being predicted for later in the week. While the current trading range of the rand probably has these strikes already priced in, any kind of violence would most likely send the South African currency into another slide. The only currency which has performed worse than the rand during 2014 is the Canadian dollar which is down just over 3%. The ‘loonie’ as the Canadian dollar is commonly called has remained under selling pressures as investors continue to bet the central bank of Canada will be easing their monetary policy. And while New Zealand is widely expected to raise rates later this year, most think this rate increase has already been priced in and therefore any signs of a delay in hiking by the RBNZ will cause the kiwi to fall. The recent moves in these commodity currencies are counter to the traditional thought that as the global economic activity picks up, commodity based currencies will move higher. But in spite of the IMF’s prediction of higher global growth, these commodity currencies remain in a bit of a funk. Weaker Chinese growth expectations have added to the negative sentiment surrounding the Australian dollar which hit a 3 ½ year low earlier this week. And with US rates starting to tick higher, the yield spread which helped support the Aussie dollar are beginning to evaporate. But data released overnight ‘down under’ showed prices had the largest rise in over two years. Prices increased 2.6% last quarter surprising most analysts who expected much tamer inflation data. Currency traders had been pricing in rate cuts, but the spike in inflation now has many of these investors shifting their positions to take advantage of a possible RBA hike during 2014. Gold fell nearly 1 percent in trading yesterday, the biggest one day drop of the short year. The drop was rumored to be the result of speculation by investors and traders that the FOMC might announce an accelerated end to its bond buying program at next week’s meeting. As Mike pointed out in yesterday’s Pfennig, investors have largely shrugged off the poor jobs numbers of a couple of weeks ago and are now focusing on the more positive signs in the US economy. This, combined with a slightly more positive outlook for the global economy has led many to abandon their ‘safe haven’ trades which typically favor precious metals. The price of all of the precious metals followed gold lower, with silver staying below $20 and platinum matching gold’s 1% decline. The price of platinum does seem to have support near the current levels as fear of a mining strike in South Africa are underpinning the price. The world’s three largest producers of platinum called the wage hikes sought by the union which is planning a strike as early as this week as ‘unaffordable and unrealistic’. We will keep an eye on the negotiations as any halt to production could signal a rebound in the price of this precious metal. And before I move to the ‘TTWT’ section, did you hear the news that Mohamed El-Erian has resigned from PIMCO? It was announced around noon yesterday that PIMCO’s CEO and Co-CIO had resigned and will leave the company in mid-March as part of a leadership overhaul. I have always enjoyed reading El-Erian’s comments, and while I don’t always agree with his thoughts I will certainly miss his views on the markets. Then there was this. Readers know I am a fan of the ‘5 Min. Forecast’ and there is obviously some mutual admiration on both sides as Chuck is frequently mentioned in the free daily recap which hits my email box each afternoon. Yesterday Chuck made ‘The 5′ again as Dave Gonigam detailed some of the stories circulating about China’s gold holdings. I think it is well known that China has been adding to their stockpiles of precious metals, but the central bank does not regularly report the total of these holdings keeping investors guessing on just how much they currently have. It is widely believed that China now holds the third largest amount of gold, behind the US and Germany. Here is what appeared in yesterday’s 5: “China may soon announce an increase in its official gold reserve from 1,054 tons to 2,710 tons,” said a Friday story from the Shanghai Daily, citing Jeffrey Nichols, managing director of American Precious Metals Advisors. Indeed, Mr. Nichols says just that on his own website: “It seems we will soon learn it bought a total of 654 tons in 2009 through 2011, another 388 tons in 2012 and more than 622 tons last year. Much of this has come from domestic mine production and secondary supply.” Add those figures to the existing 1,054 stash and you get slightly over 2,710. But where do these curiously precise figures come from? Alas, Mr. Nichols’ rationale sits behind a paywall. Still, we already know the answer… “Andrew Cosgrove and Kenneth Hoffman of Bloomberg Industries estimate that Chinese central bank holdings are likely closer to 2,710 metric tonnes — a significant increase over their disclosed amount.” That was Sprott’s David Franklin in our own virtual pages back on Nov. 8. Evidently, he got an early read on the Bloomberg Industries report, because the numbers didn’t show up in an actual Bloomberg News story until Jan. 10 of this year — days before the flurry of stories all citing this precise 2,710 metric ton figure. So we now have the Chinese media… citing a U.S. expert… making a prediction that the Chinese central bank will do its “big reveal” any day now. Stories like this don’t show up in the Chinese media by chance. Mr. Gonigan goes on to discuss Germany’s gold holdings and their request to repatriate some of these holdings. You can read the entire 5 Min. Forecast at the following. Recap. A lack of data here in the US sent currency investors to focus on UK data which showed a big improvement in their labor markets. UK unemployment rates dangerously close to their 7% threshold has propelled the pound sterling higher. The BOJ maintained their monetary policy, avoiding calls for additional stimulus to offset the possible drag of a new sales tax in April. The South African rand held steady after a 3% drop which was matched by the Canadian dollar. The Aussie dollar caught a good bid after a surprise 2.6% increase in inflation had many reversing their calls for further rate cuts ‘down under’. And finally, gold had the largest one day drop of 2014 after investors abandoned their safe haven trades. Currencies today 1/22/13. American Style: A$ .8867, kiwi .8328, C$ .9120, euro 1.3551, sterling 1.6548, Swiss $1.0984. European Style: rand 10.788, krone 6.1702, SEK 6.4902, forint 222.80, zloty 3.0719, koruna 20.291, RUB 33.92, yen 104.34, sing 1.2781, HKD 7.7572, INR 61.815, China 6.1087, pesos 13.3018, BRL 2.3618, Dollar Index 81.08, Oil $95.38, 10-year 2.85%, Silver $19.81, Platinum $1,445.80, Palladium $740.30, and Gold. $1,240.70 That’s it for today. I attended my son’s final regular season high school hockey game last night, a loss to their arch rival. The loss was a tough one, but hopefully they will bounce back and make it far into the playoffs which begin next week. I still just can’t believe his high school career is almost over; makes me feel old! But my daughter is just a freshman, so I still have a few more years of high school sports left. Boy it was a cold walk across the bridge to the office, and the temps are supposed to get even colder tomorrow – ugh! But on the positive side, we are having our chili cook off today here in the office, a perfect meal to offset those cold temperatures outside! Antione volunteered to make ours – hopefully bringing home a win for the World Markets desk. With that I will wish you all a Wonderful Wednesday, and thanks for reading the Pfennig. Chris Gaffney, CFA Vice President EverBank World Markets 1-800-926-4922 1-314-647-3837
Recommended Link — It’s Easier to Buy Legal Pot Than Straws in California. Wait Until You See What’s Coming Next…It’s true. In California you can legally buy pot… but can get arrested for selling a plastic straw. Nothing on earth has gone from taboo to billion-dollar industry faster than marijuana. While tobacco sales plummet… beer sales tumble… and the opioid crisis decimates drug makers… Big Tobacco… Big Alcohol… and Big Pharma are all turning to pot to save their industries. We’re in the middle of the biggest marijuana takeover spree in history. Watch this new video for details on three tiny pot companies that are ideal takeover targets and could be in the crosshairs of corporate giants. • Legal marijuana is one of the fastest-growing industries on the planet…The U.S. legal marijuana market is already a $6.5 billion industry. And it’s expected to grow to $50 billion by 2026. That would make it nearly three times as big as the craft beer market.But let’s be real.• The legal marijuana industry isn’t just growing rapidly…It’s eating Big Alcohol alive.In fact, a recent study found that alcohol sales fell 15% in the U.S. in states that introduced medical marijuana. In states where recreational marijuana is legal, the decline is even more pronounced.In other words, legal marijuana isn’t just an opportunity for Constellation… It’s a means of survival.It’s not the only Big Alcohol company that’s come to this realization, either.• The Molson Coors Brewing Company made its first big move into the marijuana industry last month…As I said earlier, it announced that it’s entered a joint venture with The Hydropothecary Corporation.Together, the two companies will develop non-alcoholic, cannabis-infused beverages for sale in Canada.Heineken, one of the world’s largest brewing companies, is also turning itself into a marijuana company. In fact, its Lagunitas Brewing label recently launched a new brand that will specialize in non-alcoholic, THC-infused drinks. (THC is the compound in marijuana that gets people high.)Of course, this is just the beginning.• Soon, every major alcohol company will have no choice but to “go green”…Now, some companies will try to create marijuana brands in-house. But most won’t. Instead, they’ll buy existing marijuana assets or pen deals just like Constellation and Molson Coors.So consider speculating on high-quality marijuana stocks if you haven’t yet. These companies will be prime mergers and acquisitions targets in the coming years.Just don’t wait too long to act…• The marijuana industry is rapidly consolidating…Viridian Capital Advisors recently reported that more than 145 mergers and acquisitions were announced in the U.S. and Canada during the first half of this year. That’s nearly twice as many deals as there were in the cannabis industry during the first half of last year.This tells us demand for marijuana assets is skyrocketing. And that means other Big Alcohol companies will have to inroad into the marijuana space soon. If they don’t, they’ll get left behind.• This is why I encourage you to speculate on marijuana stocks sooner rather than later…Just be sure to do a few things before diving in:Do your homework. Study a company inside and out before buying its stock. Learn about its management team. Also, don’t buy any marijuana stock on a whim or hot tip. If it sounds too good to be true, it probably is.Use discipline. Only speculate with money that you can afford to lose. Don’t chase high-flying stocks. And stick to your stop-losses.Be patient. The marijuana industry is still very young. A healthy dose of volatility is to be expected. So don’t obsess over daily swings.Regards,Justin Spittler Istanbul, Turkey August 21, 2018P.S. Crisis Investing editor Nick Giambruno just released a brand-new video presentation that reveals even more proof that now is the time to bet on marijuana stocks.You see, until now, 99% of the largest hedge funds and banks wouldn’t touch pot. That’s about to change… The “Trillion Dollar Mainstream Marijuana Takeover” begins as soon as November 6.And Nick’s discovered three tiny pot companies that could be in the crosshairs of these big funds. Well-positioned investors could see gains of 7,500%… 9,329%… even 12,547% if these companies get taken over. Click here to learn more about this rare opportunity.Chart of the Day: The Number of Banks Is ShrinkingBy E.B. Tucker, editor, Strategic InvestorThe number of U.S. banks continues to fall…As you can see in the chart below, there are 65% fewer banks in the U.S. today than in the early 1980s.That’s a dramatic decline… But I believe there will be half as many banks at the turn of the next cycle.And it’s opening up a profit opportunity…You see, earlier this year, President Trump signed a bill into law that reduces regulations on all but the largest U.S. banks. I believe this is just the beginning… It’s now only a matter of time before Trump repeals more Obama-era banking regulations.This is obviously good news for banks—specifically regional banks, like the kind we own in my Strategic Investor newsletter.It means they’ll spend less money on compliance, and more money on growing their businesses. They’ll become more profitable. As a result, they’ll have more cash to go out and acquire other banks.This is one of the best setups I’ve seen for banks in my entire career.Keep in mind, banks had excessive risk on their books going into the last crisis. The government caged them for 10 years. The Trump administration is openly saying it plans to set them free. This is a trend we don’t want to miss.—E.B. TuckerP.S. I just released a new video with more on why you need to own bank stocks today.You see, in 2008—in one of the biggest cons in American history—taxpayer funds were abused by the bank bailout. Washington elites gave the mega-banks $245 billion.The money you paid to Uncle Sam over the past 10 years went to ungrateful executives and their million-dollar yachts. And rather than return the favor… these bankers cut your income from savings accounts and CDs to nearly zero.But now, American citizens can be “compensated” for this outrageous filching of our money. It’s through what I call “Bailout Compensation Checks” or “Comp Checks” for short… Click here to see how you can access yours today.Reader MailbagToday, a reader responds to Nick Giambruno’s recent essay: “Federal Hemp Bill Will Make This Niche Industry Surge”…I love your article about CBD [cannabidiol] oil from industrial hemp. I agree 100% with what you have reported and have already invested in a few pot stocks. Like most pot stocks, they trade on the OTC exchange. My wife is suffering from a neurological problem and since I haven’t found a doctor in my area that knows much about CBD, I found a company in Colorado that produces the CBD oil from industrial hemp. I have ordered a bottle to try. I’m hoping this is the miracle we are looking for.—WilliamAs always, if you have any questions or suggestions for the Dispatch, send them to us right here. By Justin Spittler, editor, Casey Daily DispatchWe just witnessed the biggest “drug deal” of our time.…but it didn’t involve cartels or gangsters.No, this deal was forged between two giant North American corporations—Constellation Brands and Canopy Growth Corporation.Constellation is the third-largest U.S. beer company and owner of the popular Corona brand.Canopy, on the other hand, is the world’s biggest cannabis company. It serves more than 55,000 medical marijuana patients in Canada.Now this might seem like a strange pair. But this deal makes a lot of sense. In fact, Constellation basically had to make this deal. I’ll explain why in a second.But first, let me say a few things about this blockbuster deal…• Last Wednesday, Constellation announced that it will invest $4 billion in Canopy…In exchange, Constellation will receive a 38% stake in the cannabis giant.That makes this the biggest legal cannabis deal in history—by far.Of course, this isn’t the first time that Constellation has invested in Canopy. In October, it paid $191 million for a 10% stake in Canopy…This new deal nearly quadruples Constellation’s stake. — Recommended Link • Canopy’s stock surged 35% the day after the announcement…And it’s up 59% since then…Canopy’s stock is now up 215% since Constellation first invested in it 10 months ago.That’s an enormous move. But regular readers saw this coming from a mile away.• I’ve been saying for months that Big Alcohol would enter the cannabis space…In December, I told you that a “cannabis takeover mania is underway.” I said there would be a lot more dealmaking in the cannabis space.In March, I told you “Big Alcohol hasn’t been this scared since Prohibition.” I showed you why the Molson Coors Brewing Company called marijuana one of the biggest threats to its business—and that it would soon have to turn itself into a marijuana company.Then, earlier this month, I showed you that we were spot-on with our call—Coors announced that it entered a joint venture with The Hydropothecary Corporation, a Canadian cannabis producer.Now, I didn’t write this essay to brag. I wrote it because I believe we’ll see many more deals like this in the coming months… and I want you to be ready for that.After all, investors who get ahead of deals like this can make 20%… 30%… or even 40% in a day.I’ll show you how to set yourself up for those kinds of gains in a minute. But let me say a few more words on the Constellation–Canopy deal.• Constellation paid a fortune for its stake in Canopy…I don’t say this just because Constellation shelled out $4 billion.I say this because Constellation paid $4 billion and only got a 38% stake in Canopy. Let me explain…Before the deal was announced, Canopy was worth around $5 billion. So, a $4 billion investment (plus the $191 million that it already invested) should have given Constellation a much bigger stake… but it ended up with less than half of the company.This tells me Constellation sees an incredible opportunity in the legal marijuana market. Why else would it pay such a steep premium?But don’t take my word for it. Constellation CEO Robert Sands said he pulled the trigger on this deal because cannabis is a “tremendous growth opportunity.”And he’s right. Strange towers appearing in major urban areasHave you seen these strange-looking metal poles in your city? Most people have no idea what they’re for. But in just a few short years, these towers could completely upend the entire $479 billion smartphone industry… and make well-positioned investors rich. If you want to be one of them… and get ahead of this transformational trend… click here.
The tall, gangly man twists a cone of paper in his hands as stories from nearly 30 years of addiction pour out: the robbery that landed him in prison at 17; never getting his GED; going through the horrors of detox, maybe 40 times, including this latest, which he finished two weeks ago. He’s now in a residential unit for at least 30 days.”I’m a serious addict,” says Julio Cesar Santiago, 44. “I still have dreams where I’m about to use drugs, and I have to wake up and get on my knees and pray, ‘let God take this away from me,’ because I don’t want to go back. I know that if I go back out there, I’m done.”Santiago has some reason to worry. Data on opioid addiction in his home state of Massachusetts shows the overdose death rate for Latinos there has doubled in three years, growing at twice the rate of whites and blacks.Opioid overdose deaths among Latinos are surging nationwide as well. While the overall death toll is still higher for whites, it’s increasing faster for Latinos and blacks, according to data from the Centers for Disease Control and Prevention. Latino fatalities increased 52.5 percent between 2014 and 2016 as compared to 45.8 percent for whites. (Statisticians say counts for Hispanics are typically underestimated by 3 to 5 percent.) The most substantial hike was among blacks — 83.9 percent.The data portrays a changing face of the opioid epidemic.”What we thought initially, that this was a problem among non-Hispanic whites, is not quite accurate,” says Robert Anderson, mortality statistics branch chief at the CDC’s National Center for Health Statistics. “If you go back into the data, you can see the increases over time in all of these groups, but we tended to focus on the non-Hispanic whites because the rates were so much higher.”There’s little understanding about why overdose deaths are rising faster among blacks and Latinos than whites. Some physicians and outreach workers suspect the infiltration of fentanyl into cocaine is driving up fatalities among blacks.The picture of what’s happening among Latinos has been murky, but interviews with nearly two dozen current and former drug users and their family members, addiction treatment providers and physicians reveal language and cultural barriers and even fear of deportation could be limiting the access of Latinos to life-saving treatment.Few bilingual treatment options Irma Bermudez, 43, describes herself as a “grateful recovering addict.” She’s living in the women’s residential unit at Casa Esperanza, a collection of day treatment, residential programs and transitional housing in Boston’s Roxbury neighborhood.Bermudez says the language barrier keeps anyone who can’t read English out of treatment from the start, as they try to decipher websites or brochures that advertise options. If they call a number on the screen or walk into an office, “there’s no translation — we’re not going to get nothing out of it,” Bermudez says.Some of the Latinos interviewed for this story describe sitting through group counseling sessions, part of virtually every treatment program, and not being able to follow much, if any, of the conversation. They recall waiting for a translator to arrive for their individual appointment with a doctor or counselor and missing the session when the translator is late or doesn’t show up at all.SAMHSA, the federal Substance Abuse and Mental Health Services Administration, maintains a Find Treatment website which includes listings of treatment offered in Spanish. But several Massachusetts providers listed there could not say how many translators they have or when they are available. The SAMHSA site is only available in English, with Spanish-language translators only available by phone.At Casa Esperanza, 100 men are waiting for a spot in the male residential program, so recovery coach Richard Lopez spends a lot time on the phone trying to get clients into a program he thinks has at least one translator.After battling with voicemail, says Lopez, he’ll eventually get a call back; the agent typically offers to put Lopez’s client on another waiting list. It frustrates him.”You’re telling me that this person has to wait two to three months? I’m trying to save this person today,” he says. “What am I going to do, bring these individuals to my house and handcuff them so they don’t do nothing?”Casa Esperanza Executive Director Emily Stewart says Massachusetts needs a public information campaign via Spanish-language media that explains treatment options. She’d like that to include medication-assisted treatment, which she says is not well understood.Some research shows Latino drug users are less likely than others to have access to or use the addiction treatment medicines, methadone and buprenorphine. One study shows that may be shifting. But, Latinos with experience in the field say, access to buprenorphine (which is also known by the brand name Suboxone) is limited because there are few Spanish-speaking doctors who prescribe it.Cultural barriers — ‘It’s not cool to call 911’Lopez has close ties these days with health care providers, the police and EMTs. But that has changed dramatically from when he was using heroin. On the streets, he says,”It’s not cool to be calling 911,” when a person sees someone overdose. “I could get shot, and I won’t call 911.”It’s a machismo thing, says Lopez.”To the men in the house, the word ‘help,’ sounds like degrading, you know?” he says. Calling 911 “is like you’re getting exiled from your community.”Santiago says not everyone feels that way. A few men called EMTs to help revive him. “I wouldn’t be here today if it wasn’t for them,” he says.But Santiago and others say there’s growing fear among Latinos they know of asking anyone perceived as a government agent for help — especially if the person who needs the help is not a U.S. citizen.”They fear if they get involved they’re going to get deported,” says Felito Diaz, 41.Bermudez says Latino women have their own reasons to worry about calling 911 if a boyfriend or husband has stopped breathing.”If they are in a relationship and trying to protect someone, they might hesitate as well,” says Bermudez, if the man would face arrest and possible jail time.Ties in the communityAnother reason some Latino drug users say they’ve been hit especially hard by this epidemic: A 2017 DEA report on drug trafficking noted that Mexican cartels control much of the illegal drug distribution in the United States, selling the drugs through a network of local gangs and small-scale dealers.In the Northeast, Dominican drug dealers tend to predominate.”The Latinos are the ones bringing in the drugs here,” says Rafael, a man who uses heroin and lives on the street in Boston, close to Casa Esperanza. “The Latinos are getting their hands in it, and they’re liking it.”NPR agreed not to use Rafael’s last name because he uses illegal drugs.Some Spanish-speaking drug users in the Boston area say they get discounts on the first, most potent cut. Social connection matters, they say.”Of course, I would feel more comfortable selling to a Latino if I was a drug dealer than a Caucasian or any other, because I know how to relate and get that money off them,” says Lopez.The social networks of drug use create another layer of challenges for some Latinos, says Dr. Chinazo Cunningham, who treats many patients from Puerto Rico. She primarily works at a clinic affiliated with the Montefiore Medical Center in the Bronx, in New York City.”The family is such an important unit — it’s difficult if there is substance use within the family for people to stop using opioids,” Cunningham says.The burden of povertyThough Latinos are hardly a uniform community, many face an additional risk factor for addiction: poverty. About 20 percent of the community lives in poverty, compared to 9 percent of whites according to the Kaiser Family Foundation. In Massachusetts, four times as many Latinos live below the poverty line as do whites. The majority of Casa Esperanza clients were recently homeless. The wait time for one of the agency’s 37 individual or family housing units ranges from a year to a decade.”If you’ve done all the work of getting somebody stabilized and then they leave and don’t have a stable place to go, you’re right back where you started,” says Casa Esperanza’s Stewart.Cunningham says the Latino community has been dealing with opioid addiction for decades and it is one reason for the group’s relatively high incarceration rate. In Massachusetts, Latinos are sentenced to prison at five times the rate of whites.”It’s great that we’re now talking about it because the opioid epidemic is affecting other populations,” Cunningham says. “It’s a little bit bittersweet that this hasn’t been addressed years before. But it’s good that we’re talking about treatment rather than incarceration, and that this is a medical illness rather than a moral shortcoming.”Nationally, says the CDC’s Anderson, there’s no sign that the surge of overdose deaths is abating in any population.”We’ve already had two years of declining life expectancy in the U.S. and I think that when we see the 2017 data we’ll see a third year,” says Anderson. “That hasn’t happened since the great influenza pandemic in the early 1900s.”The death numbers for 2017 are expected out by the end of this year.This story is part of a reporting partnership with NPR, WBUR and Kaiser Health News. Copyright 2018 WBUR. To see more, visit WBUR.
What do you do when a hospital emergency room tacks on an “after-hours” service charge, and your insurer threatens to not pay it? What happens when Medicare and workers’ compensation disagree about which should cover your medical bill? We have answers to these and other questions from readers:I visited a local emergency room one night after I had a severe allergic reaction that caused intense itching, hives, swelling and blistering. Now I’ve received an “explanation of benefits” notice from my insurer that I will be billed by the in-network hospital for “after-hours” service. My insurer does not cover that charge. I am so enraged. Is there anything I can do to get the hospital to remove the charge?That sort of charge, though pretty rare — is defensible, says Dr. Paul Kivela, an emergency physician in Napa, Calif., who is president of the American College of Emergency Physicians. He notes that the cost of staffing an emergency department at night is higher than by day. The surcharge is typically modest (often less than $100), according to billing specialists.But that’s neither here nor there, says Betsy Imholz, special projects director for the advocacy group Consumers Union. She thinks the extra charge should have been built into the overall rate.”It’s infuriating,” Imholz says. “I don’t blame [the patient] for being annoyed.”Just because your health plan initially balks at paying the surcharge, that may not be the final word, says Richard Gundling, a senior vice president at the Healthcare Financial Management Association, a trade group for the health care finance industry. Hospitals and insurers frequently sort out these surcharges between themselves, without holding patients responsible.”If it’s an in-network provider, an insurer is generally responsible for addressing the billing of that code under its negotiated contract with the providers,” Gundling says.Medicare beneficiaries are not responsible for paying the surcharge.If the hospital pursues the patient to pay the charge, Imholz recommends that consumers file an appeal with their health plan. Appeals on many issues are frequently successful, he says.I fell in 2015 and my injuries are being covered by the workers’ compensation program. It pays only the claims that are related to my back and neck injuries. But Medicare has been refusing all the claims it receives, including a hospital stay for an acute asthma attack, as well as routine visits to my primary care physician. The program states that these claims are the responsibility of workers’ comp. What can I do?Your workers’ compensation insurer is the “primary payer” for medical bills that are related to your work-related injury. Medicare is responsible for your other medical care.Without more information, it’s impossible to know exactly why Medicare is denying your claims.However, the problem may be rooted in the mandatory data-reporting requirements that the federal Centers for Medicare & Medicaid Services put in place about a decade ago, says Darrell Brown, an executive vice president and chief claims officer at Sedgwick Claims Management Services.Under the federal rules, insurers and plan administrators have to report claims data about Medicare beneficiaries who are also covered by a group health plan or who receive payments under workers’ compensation. The aim is to ensure that the Medicare program isn’t acting as a primary payer on some claims when another health plan or program should be doing so.”My guess is that there’s something that went wrong with that reporting,” Brown says. “There’s so much data that they’re getting, and there’s so much room for error as well.”Start by contacting the number or person on the notice you received from the Medicare program denying your claim, Brown advises. You may also have to contact the workers’ compensation insurance carrier. But your first step should be to find out why the Medicare program mistakenly believes that your asthma hospitalization and other care are related to your workers’ comp injury.Why is there a new exemption from the penalty for not having health insurance if you live in a bare county with no marketplace insurers? There aren’t any of those, and next year there’s no penalty. So what’s the point?As you note, starting next year, people will no longer owe a penalty for not meeting the Affordable Care Act’s requirement of having health insurance.People will, however, be able to apply to the marketplace for a hardship exemption if they live somewhere where there are no marketplace insurers — a “bare county.”That may give them another option for coverage.People who qualify for a hardship or affordability exemption can receive an “exemption certificate number,” often referred to as an ECN, which will allow them to buy a catastrophic plan that meets the Affordable Care Act standards — a type of health insurance policy that is usually available only to people under age 30, says Tara Straw, a senior policy analyst at the Center on Budget and Policy Priorities.These ACA-compliant plans may be purchased outside the exchange, even if no insurers are selling marketplace plans in a particular area.These catastrophic plans cover the essential health benefits. They often have lower premiums than bronze or other “metal plans” on the ACA marketplace entail, but their deductibles are comparatively very high, and people can’t receive premium tax credits to pay for them.The high out-of-pocket costs may explain why they haven’t been popular. Fewer than 1 percent of marketplace enrollees picked one in 2018.Kaiser Health News, a nonprofit news service, is an editorially independent program of the Kaiser Family Foundation that is not affiliated with Kaiser Permanente. Follow Michelle Andrews on Twitter: @mandrews110. Copyright 2018 Kaiser Health News. To see more, visit Kaiser Health News.
In a move it said was to address the large cost of entering a career in medicine, New York University’s School of Medicine said Thursday that it will offer full scholarships to all current and future students in its doctor of medicine program.NYU said it was the “only top 10-ranked” medical school in the U.S. to offer such a generous package.”I’m proud to announce that as of right now, every student that we admit to New York University School of Medicine comes tuition-free,” Kenneth G. Langone, chair of the board of trustees, said in a video announcement Thursday. “And this includes the incoming class and the upperclassmen as well that are here right now — no more tuition.””They walk out of here unencumbered, looking at a future where they can do what their passion tells them, which is to help people live better quality lives,” he added.The program covers a yearly tuition of $55,018, NYU says. Students will not have a totally free ride, however. According to The Wall Street Journal, most medical students will still foot the bill for about $29,000 each year in room, board and other living expenses. The scholarships will help 93 first-year students along with 350 already partially through the program, the Journal reports. Several students enrolled in a joint MD/Ph.D. program are already offered free tuition under a separate program.Three out of four medical school graduates in 2017 graduated in debt, according to the Association of American Medical Colleges. Of those in debt, the median amount was $192,000, the group says.NYU also says medical school debt is “reshaping the medical profession,” as graduates choose more lucrative specialized fields in medicine rather than primary care. A report from the AAMC in April said the U.S. faces a shortage of doctors of all types — perhaps more than 120,000 by 2030. The predictions vary widely, however, to between 42,600 and 121,300. The group says the country will be lacking between 14,800 and 49,300 primary care physicians by 2030, while “non-primary care specialties” will fall short by 33,800 and 72,700 doctors. NYU’s announcement follows Columbia University saying in December that its medical school would offer full-tuition scholarships to certain students in need, along with grants to other students.NYU said the free tuition would cost about $600 million to fund indefinitely, and that it had raised $450 million of that already, according to The New York Times. Langone, who founded Home Depot, and his wife Elaine, contributed $100 million of that total. The school says it hopes the plan will also increase diversity among its students — what it calls “a full retrofitting of the pipeline that trains and finances” future doctors. The AAMC reported almost 90,000 students enrolled in U.S. medical schools for the 2017-2018 school year. About 52 percent of them identified as white, 21 percent as Asian, 8 percent as multiple race/ethnicity, 7 percent as African-American, and 6 percent as Hispanic or Latino, and smaller percentages for other groups. Copyright 2018 NPR. To see more, visit http://www.npr.org/.
Alzheimer’s disease begins altering the brain long before it affects memory and thinking.So scientists are developing a range of tests to detect these changes in the brain, which include an increase in toxic proteins, inflammation and damage to the connections between brain cells. The tests rely on biomarkers, shorthand for biological markers, that signal steps along the progression of disease. These new tests are already making Alzheimer’s diagnosis more accurate, and helping pharmaceutical companies test new drugs. “For the future, we hope that we might be able to use these biomarkers in order to stop or delay the memory changes from ever happening,” says Maria Carrillo, chief science officer of the Alzheimer’s Association. (The association is a recent NPR sponsor.)The first Alzheimer’s biomarker test was approved by the Food and Drug Administration in in 2012. It’s a dye called Amyvid that reveals clumps of a protein called amyloid. These amyloid plaques are a hallmark of Alzheimer’s.Before Amyvid came along, diagnosing the disease involved a lot of guesswork, says Dr. Howard Fillit, founding executive director and chief science officer at the Alzheimer’s Drug Discovery Foundation.”I can now send a patient down the block to the radiology office and within 24 hours with 98% certainty I can tell people if they have Alzheimer’s disease,” Fillit says.The test costs thousands of dollars, though, in part because it requires a PET scan of the brain. Also, Amyvid reveals only amyloid plaques, which are just one of the brain changes associated with Alzheimer’s. So the Alzheimer’s Drug Discovery Foundation has launched an effort to speed up development of biomarkers that are cheaper and detect a wider range of brain changes.One promising test detects the protein tau, which causes toxic tangles to form inside brain cells.”The tangles represent the dying neurons,” Fillit says, which means a biomarker for tau could make diagnosing Alzheimer’s even more accurate. It could also help pharmaceutical companies assess experimental drugs meant to remove tau from the brain.Several drug companies appear close to receiving FDA approval for injected dyes that reveal tau in patients who get PET scans.And eventually, scientists hope to use biomarkers in spinal fluid and blood to assess levels of both amyloid and tau in the brain. Those tests promise to be easier for patients, and less expensive to administer.But even detecting amyloid and tau in the brain won’t be enough, Fillit says. People can have high levels of both and still do pretty well until something else shows up in the brain: inflammation.”It’s like having the highest sensitivity computer up there and throwing coffee on it,” Fillit says.So researchers are working to identify biomarkers for inflammation.They’re also working on a biomarker that indicates the health of synapses, the connections between brain cells. Weakening synapses are one of the surest signs of Alzheimer’s, Fillit says. “So we’re funding a clinical trial at a company that is going to use this biomarker as a measure of how well their drug is preserving synapses in the hippocampus of people with Alzheimer’s disease.”Biomarkers for Alzheimer’s are still a work in progress. For example, they will have to be tested in many different populations.”What may represent as a biomarker in one population may not actually hold true in another, and we’ve seen this in other diseases,” says the Alzheimer Association’s Carrillo.Also, biomarkers still don’t offer a reliable way to measure a person’s mental function. They only reveal the brain changes that are associated with loss of memory and difficulty thinking.Even so, over time the arrival of new markers should make treating Alzheimer’s more like treating other diseases, Carrillo says.”We treat high cholesterol to reduce the risk of that heart attack,” she says. And someday it may be possible to reduce the risk of dementia by treating high levels of amyloid, tau or inflammation in the brain. Copyright 2019 NPR. To see more, visit https://www.npr.org.
Staff Writer. Covers leadership, media, technology and culture. –shares There are probably some odd things that people would do for a good discount, but this is a new one. In Sweden, furniture maker and meatball purveyor Ikea has released its first magazine advertisement of 2018, and the company has included some, let’s say interesting, technology in the ad.The advertisement is meant for expectant families, as it features a stylish black crib and reads “peeing on this ad may change your life.” Yep, if you’re a pregnant lady and you pee on the paper, a reduced price for the crib will be revealed as part of the Ikea Family Discount. Related: Ikea Designers Using Mars Simulator for Ideas Understand a Secret About CreativityThe process was developed by Swedish advertising firm Åkestam Holst and biotech startup Mercene Labs. And apparently, Ikea is not the first company to go for a pee-oriented advertisement. Back in 2001, to promote a dog awards show, Animal Planet placed ads that had dog urine scent at the base of lamp posts to get a canine’s, and, by extension, a human’s attention.IKEA’s pee ad isn’t even the first pee ad.I love this world. @Adweek pic.twitter.com/RExSZI3q5a— Bronwyn (@bronwynbails) January 9, 2018Ostensibly you can then bring in the coupon to purchase a new crib. And so far, the response seems to be positive — at least from fellow creatives in the ad world, who even think the pee ad is an innovative move. “With digital media prone to tying itself into knots of complexity, this ’traditional media’ print ad shows how to do interactivity powerfully,” The Core Agency founder Jon Skinner told Adnews.com.This ad seems to be the most recent in a long line of offbeat promotions — like commissioning of a peregrine falcon statue made of Allen wrenches to open a store in Sheffield, England or the company’s response to Balenciaga’s $2,145 leather version of it’s blue bag. Clearly Ikea isn’t taking itself too seriously.Still, we have some questions and concerns regarding…logistics.Related: IKEA’s ‘Open Platform’ Embraces Furniture HackingChiefly, think of the poor cashiers and and sales personnel who might have to handle the coupon. Will there be plastic bags and latex gloves involved to get it to the store? Can you redeem it online? There has to be a better way to get a furniture discount. We’re all for ingenuity and innovation, but mostly, our main question is, why?We’ve reached out to Ikea for clarification and will update with any additional information. Free Webinar | July 31: Secrets to Running a Successful Family Business Ikea Is Asking Women to Pee on This Ad, and We’ve Got Questions The magazine ad is aimed at pregnant women, in case you’re wondering. Image credit: IKEA Learn how to successfully navigate family business dynamics and build businesses that excel. Nina Zipkin Entrepreneur Staff Add to Queue 3 min read Advertising Next Article January 10, 2018 Register Now »
Investment to further accelerate tech innovation, fuel international growth, and bolster company vision as the operating system for marketingNewsCred, the world’s leading enterprise content marketing platform (CMP) provider, announced an additional $20 million in financing; capital that will help accelerate R&D innovation, fuel the company’s rapid global expansion, and support the growing demand for the Integrated Marketing Edition of its CMP. Led by InterWest Partners, with new participation from strategic partner Dentsu Inc. as well as Escalate Capital Partners, this investment brings the total invested capital in NewsCred to over $100 million — the largest in its category. All major existing investors also participated in the round, including FTV Capital, Mayfield Fund, FirstMark Capital and Greycroft.Marketing Technology News: JotForm Reaches 5 Millionth User After Major LaunchJust over 10 years old, NewsCred has firmly established itself as the leader of its category, positioned highest and furthest to the right in Gartner’s Magic Quadrant for Content Marketing Platforms for two consecutive years. Combining its domain expertise and industry-leading platform — recently enhanced with strategic planning and global collaboration tools — the company is now setting out to modernize how global marketing organizations work.”This latest round of funding will help us double down on our mission to unleash the potential of marketing teams,” said Shafqat Islam, Co-Founder & CEO of NewsCred. “Not only do we have the most invested capital in the category, but we are also the largest in terms of revenue. Our traction in the enterprise market is a testament to the confidence that customers have in our business as well as our mission. The future is bright, and we are excited to continue supporting our customers in pioneering a new, modern era of marketing.”Marketing Technology News: Wix and FaZe Clan Launch Global PartnershipOver the last 12 months, NewsCred launched the Integrated Marketing Edition of its CMP, introducing new campaign planning and project management functionality designed to unify global marketing organizations.Now, this latest round of financing positions NewsCred to:Increase R&D investment in its integrated marketing and work management capabilities, as well as broaden its integration stack for interoperability with the wider marketing tech ecosystemExpand existing field operations in the US, EMEA, and APAC to increase competitive displacements and accelerate growth in those regionsBolster its ability to support a growing enterprise customer base with best-in-class marketing software and services“We believe that Content Marketing Platforms are equipped to become the strategic centerpiece for modern marketing organizations,” said Shafqat. “By bridging the gap from campaign planning to content creation, providing tools to streamline execution, and surfacing analytics across operational efficiency and campaign performance, we are empowering global marketing organizations to transform how they work, deliver exceptional content, and elevate the impact of their marketing efforts.”Marketing Technology News: Seal Software Announces Executive Leadership Changes NewsCred Announces $20 Million in Additional Financing; Takes Aim at Global Marketing Transformation Business WireJuly 12, 2019, 9:00 pmJuly 12, 2019 content marketingglobal marketingMarketing Technology NewsNewsNewsCredShafqat Islam Previous ArticleTechSee Launches Industry’s First Visual Automation Solution for Contact CentersNext ArticleConga Study: Documents are Going Digital but 76% of Companies Yet to Fully Transform
We were able to replicate the findings of the elevated PKM2 in those with good kidney function in both type 1 and type 2 diabetes. Also, through the plasma proteomic and metabolomic studies in the Medalists, we found that there’s this amyloid precursor protein, or APP, that shows up as a potential protective factor against diabetic kidney disease.”Hetal Shah, MD,MPH, Research Associate at Joslin Diabetes Center Related StoriesCommon metric may not accurately assess kidney function of Indian patientsNew imaging probe allows earlier detection of acute kidney failureBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryThe identification of APP as a possible protective factor was surprising, considering its main known association is an increased risk for Alzheimer’s disease.”[But it also seems to be] potentially protective in multiple vulnerable tissues in people with diabetes. With that said, we would need further studies to confirm this,” says Dr. Shah.Understanding the DKD protective factors could have clinical implications. If a biomarker circulates in the bloodstream, it could allow doctors to perform a simple blood test to determine a patient’s risk for developing DKD. They could then create personalized intervention courses.Once the protective mechanisms are explicitly mapped, they could even be used as therapeutic targets.”Diabetic kidney disease is a devastating disease,” says Dr. Gordin. “It is a powerful driver of cardiovascular disease, and also, eventually, mortality. We have urgent need to find something to help these people. All [these studies] take time, but this is very promising.”Source:Joslin Diabetes CenterJournal reference:Shah, H. et al. (2019) Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy. Diabetes Care. doi.org/10.2337/dc18-2585 Reviewed by James Ives, M.Psych. (Editor)May 21 2019A new study from Joslin Diabetes Center has proven that certain biological protective factors play a large role in preventing diabetic kidney disease in certain people. The study was published today in Diabetes Care.This study built on the findings from a 2017 Joslin Medalist Study of protective factors and diabetic kidney disease (or DKD). The 2017 study focused on Joslin Medalists- people who have had diabetes for more than 50 years with little to no complications. The Medalists who never developed kidney disease had higher levels of a group of enzymes involved in glucose metabolism than people who did develop kidney disease.The research team was led by Hetal Shah, MD,MPH, Research Associate at Joslin Diabetes Center and HMS Instructor in Medicine, Daniel Gordin, MD, PhD, Adjunct faculty at Joslin and Associate Professor at University of Helsinki, Finland, and George King, MD, Joslin Senior Vice President and Chief Scientific Officer and HMS Professor in Medicine,In their new study, Drs. Shah, Gordin and King were able to show that protective factors are also present in kidney-disease-free people with shorter-duration type 1 diabetes and type 2 diabetes. This finding indicates that these enzymes, and one in particular known as PKM2, play a strong protective role against kidney disease. The enzymes could be used as both biomarkers and, potentially, targets for DKD intervention.Kidney disease is a major concern for people with diabetes. But not everyone with type 1 diabetes develops DKD. The fact that Joslin Medalists have such low rates of complications has intrigued researchers’ worldwide.”That built up the rationale that there must be something protecting these people from diabetic kidney disease. This would explain how these individuals have been able to live with insulin dependent diabetes for so many years,” says Dr. Gordin.The researchers set out to investigate three questions related to the 2017 discovery. First- was PKM2 protective in non-Medalists? Second- was PKM2 circulating in the Medalists’ plasma, or was it only found in the kidney? And third- do the Medalists have any other protective factors to be explored?To answer the first question, they studied the postmortem kidneys donated by people in all of the cohorts they wanted to investigate. For the second question, they used cutting edge proteomic and metabolomic techniques to study the circulating plasma of Medalists. For the third question, they looked at the plasma and identified a number of metabolites and proteins that were also elevated. They mapped the associated genetic pathways to understand the cause and effect of the elevations.
Press Trust of India JammuJuly 13, 2019UPDATED: July 13, 2019 17:55 IST PTI image used for representation.Pilgrimage to the cave shrine of Amarnath was suspended for Saturday as a precautionary measure in view of a separatists-sponsored strike in the Kashmir valley on Martyrs’ Day, officials said.As many as 12 batches of pilgrims have so far left for the twin base camps of Pahalgam and Baltal in Kashmir valley from Jammu since the beginning of the pilgrimage on June 30.”Amarnath yatra has been suspended from Jammu as a precautionary measure in wake of the strike called by separatists in Kashmir valley Saturday,” an official said.July 13 is observed as Martyrs’ Day in Kashmir. On this day in 1931, 22 people were killed in firing by the forces of Dogra ruler Maharaja Hari Singh.Separatists have called for a shutdown as a mark of respect to those killed in the firing.On July 8, the pilgrimage was suspended as a precautionary measure in view of the third death anniversary of former Hizbul Mujahideen commander Burhan Wani.Due to the strike, normal life was severely affected in the valley as shops and other business establishments remained closed, while public transport remained off roads, the officials said.They said some private vehicles, however, were plying in intra-city and inter-district routes of Kashmir.Over 1.50 lakh pilgrims have paid obeisance at the cave shrine in the last 12 days of the Amarnath yatra.Over 1.75 lakh pilgrims have so far registered themselves for the 46-day long pilgrimage, which is through the 36-km Pahalgam track in Jammu and Kashmir’s Anantnag district and the shorter 14-km Baltal route in Ganderbal district.The pilgrimage commenced on July 1 from both Baltal and Pahalgam routes. Multi-tier security arrangements were made for the smooth and successful conduct of the yatra that concludes on August 15.As many as 2.85 lakh pilgrims had paid obeisance at the cave last year, while the number of pilgrims was 3.52 lakh in 2015, 3,20 lakh in 2016 and 2.60 lakh in 2017.Also Read | 13,004 pilgrims pay obeisance at Amarnath cave shrineAlso Read | Jammu Darshan bus service launched in J&K to promote tourismAlso Watch | First batch of Amarnath pilgrims reaches shrineFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Next Amarnath Yatra suspended for Saturday due to separatist-backed strike in KashmirAs many as 12 batches of pilgrims have so far left for the twin base camps of Pahalgam and Baltal in Kashmir valley from Jammu since the beginning of the pilgrimage on June 30.advertisement